In Diablo 4, you will need to use Unique weapons and gear to make the most out of your build. These Unique weapons are powerful items, that come with some amazing rolls that are aimed at increasing the efficiency of a build.
There are a lot of Uniques in the game, and almost all of them drop from monsters in the open world, but the drop rates are low.
To combat that, the developers introduced endgame bosses in Diablo 4 so that you can target farm the Uniques you need.
So here’s a guide that will help you figure out the loot tables for all the endgame bosses in Diablo 4 and the Uniques that they drop.
All endgame bosses in Diablo 4 and their loot tables
In Diablo 4, you will come across six endgame bosses, each with a loot table of their own. These bosses are as follows:
- Beast in Ice
- Lord Zir
- Grigoire, The Galvanic Saint
- Varshan
- Duriel
- Andariel
To face these bosses and farm their Uniques in Diablo 4, you need to get your hands on some summoning materials. You then need to get to a pedestal within a dungeon to summon and then defeat them.
It’s also worth noting that for the best possible rewards, you need to defeat these bosses in World Tier 4. Here’s a list of the loot tables for all the bosses in Diablo 4.
Varshan

How to summon: Use maligant body parts that drop from Whisper Caches and Grotesque Debtors at the Malignant Burrow under the Tree of Whispers.
Class | Unique |
---|---|
Barbarian | Ring of Red Furor, Fields of Crimson, 100,000 Steps, Gohr’s Devastating Grips |
Druid | Airidah’s Inexorable Will, Mad Wolf’s Glee, Vasily’s Prayer, Greatstaff of the Crone |
Necromancer | Ring of the Sacrilegious Soul, Bloodless Scream, Deathless Visage, Deathspeaker’s Pendant |
Rogue | Writhing Band of Trickery, Condemnation, Eyes in the Dark, Skyhunter |
Sorcerer | Tal Rasha’s Iridescent Loop, Staff of Endless Rage, Esu’s Heirloom, Raiment of the Infinite |
Universal | Frostburn, Mother’s Embrace |
Lord Zir

How to summon: Use Exquisite Blood that drops from Legion Events at The Ancient Seat in Fractured Peaks.
Class | Unique |
---|---|
Barbarian | Ramaladni’s Magnus Opus, Rage of Harrogath, Gohr’s Devastating Grips, Overkill, The Butcher’s Cleaver |
Druid | Mad Wolf’s Glee, Vasily’s Prayer, Greatstaff of the Crone, Fleshrender, The Butcher’s Cleaver |
Necromancer | Blood Artisan’s Cuirass, Deathless Visage, Greaves of the Empty Tomb, Lidless Wall |
Rogue | Grasp of Shadow, Eyes in the Dark, Skyhunter, Asheara’s Khanjar |
Sorcerer | Staff of Endless Rage, Iceheart Brais, Raiment of the Infinite, Esadora’s Overflowing Cameo |
Universal | Penitent Greaves, Razorplate, Temerity |
Grigoire, The Galvanic Saint

How to summon: Collect Living Steel from Helltide Chests and deposit them at Hall of the Pentinent in Dry Steppes.
Class | Unique |
---|---|
Barbarian | Ramaladni’s Magnum Opus, Rage of Harrogath, Battle Trance, The Butcher’s Cleaver, Twin Strikes |
Druid | Insatiable Fury, Hunter’s Zenith, Waxing Gibbous, The Butcher’s Cleaver, Earthbreaker |
Necromancer | Blood Artisan’s Cuirass, Howl from Below, Greaves of the Empty Tomb, Ebonpiercer |
Rogue | Word of Hakan, Grasp of Shadow, Windforce, Saboteur’s Signet |
Sorcerer | Staff of Lam Esen, Iceheart Brais, Gloves of the Illuminator, Flameweaver |
Universal | Penitent Greaves |
Beast in Ice

How to summon: Collect Distilled Fear from Level 30 Nightmare Dungeons and use it to craft the Glacial Fissure Nightmare Sigil.
Class | Unique |
---|---|
Barbarian | Fields of Crimson, 100,000 Steps, Ancients’ Oath, Battle Trance, Hellhammer, Ring of the Ravenous |
Druid | Insatiable Fury, Hunter’s Zenith, Waxing Gibbous, Storm’s Companion, Unsung Ascetic’s Wraps |
Necromancer | Bloodless Scream, Howl from Below, Deathspeaker’s Pendant, Ring of Mendeln, Mutilator Plate |
Rogue | Condemnation, Word of Hakan, Windforce, Eaglehorn, Beastfall Boots |
Sorcerer | Staff of Lam Esen, Esu’s Heirloom, Gloves of the Illuminator, The Oculus, Starfall Coronet |
Universal | Frostburn, Mother’s Embrace, Fists of Fate, Tassets of Dawning Sky, Paingorger’s Gauntlets |
Duriel, Lord of Maggots

How to summon: Collect Shards of Agony from Grigoire and Mucus-Slick Eggs from Varshan and then head to the Gaping Crevasse Dungeon.
Class | Unique |
---|---|
Barbarian | Tuskhelm of Joritz the Mighty |
Druid | Tempest Roar, Dolmen Stone |
Necromancer | Black River, Blood Moon Breeches |
Rogue | Cowl of the Nameless, Scoundrel’s Leathers |
Sorcerer | Flamescar, Blue Rose |
Universal | Godslayer Crown, Flickerstep, Tibault’s Will, X’Fal’s Corroded Signet, Soulbrand, Banished Lord’s Talisman |
Mythics | Doombringer (Barb, Necro, Rogue), The Grandfather (Barb, Necro), Melted Heart of Selig, Andariel’s Visage, Harlequin Crest, Tyrael’s Might, Ring of Starless Skies, Ahavarion Spear of Lycander (Druid, Sorc) |
Andariel, Maiden of Anguish

How to summon: Collect Sandscorched Shackles in Diablo 4 Season 5 from Lord Zir, and Pincushioned Dolls from The Beast in Ice to summon her at Hanged Man’s Hall.
Class | Unique |
---|---|
Barbarian | Tuskhelm of Joritz the Mighty |
Druid | Tempest Roar, Dolmen Stone |
Necromancer | Black River, Blood Moon Breeches |
Rogue | Cowl of the Nameless, Scoundrel’s Leathers |
Sorcerer | Flamescar, Blue Rose |
Universal | Godslayer Crown, Flickerstep, Tibault’s Will, X’Fal’s Corroded Signet, Soulbrand, Banished Lord’s Talisman, Azurewrath |
Mythics | Doombringer (Barb, Necro, Rogue), The Grandfather (Barb, Necro), Melted Heart of Selig, Andariel’s Visage, Harlequin Crest, Tyrael’s Might, Ring of Starless Skies, Ahavarion Spear of Lycander (Druid, Sorc) |