Warhammer 40K Space Marine 2 features different weapons that allow you to evenly match your might against the forces of Tyranid and various bosses in-game.
While you can access many weapons and grenades throughout the multiple classes of the game and the single-player story, not all of them are good.
So, if you want to pick the best weapons in Warhammer 40K Space Marine 2 and have a fighting chance against the forces of Tyranid and Chaos, here are some suggestions.
1. Thunder Hammer
The Thunder Hammer is a slow yet hard-hitting weapon that crushes enemies with every swing but unlocks relatively later in the game.

This weapon is an insanely good crowd-controlling weapon because whenever you land a hit on an enemy, they cause a huge electrical explosion, damaging everyone nearby.
Since it’s got a slow attack rate, you’re likely to take a moderate amount of damage, but you will immediately regain your health because of its great AoE potential.
2. Auto Bolt Rifle
The Auto Bolt Rifle is a very simple weapon to use in Warhammer 40K Space Marine 2. Unlike some of the weapons in the game, it does not have a learning curve, and can stop a swarm of smaller enemies with ease.

Although you will come across this weapon during the early game stages, you might stick to it for a long time, considering how simple it is to use this gun.
3. Melta Rifle
Arguably one of the most potent weapons in-game, Melta Rifle is a makeshift flamethrower with a strong stopping power. It can take out a swarm of Tyranid easily in seconds and also stop the Grunts to a certain extent.

However, the Melta Rifle has limited range and extremely long cooldown times which makes it a very situational weapon.
4. Chainsword
One of the first melee weapons you’ll access in Warhammer 40K Space Marine 2 is a Chainsword. And any seasoned fan or someone moderately aware of this universe knows how iconic this weapon is. But, outside of being iconic, Chainsword is a highly reliable weapon that can cut through enemies.

Chainsword comes equipped with the sheer stopping power of swarms of enemies. You can also perform great combos with this weapon, which looks visually appealing.
5. Bolt Carbine
Bolt Carbine is Warhammer 40K’s rendition of a sub-machine gun. It has a high fire rate, which will shred swarms of enemies thanks to that. So, you should use a Bolt Carbine when going against a Tyranid swarm.

And while it doesn’t have much damage compared to its counterparts, its rate-of-fire makes it a one-of-the-kind weapon against swarms. A few continuous shots will melt a whole swarm of Tyranid with ease.