Winning more rounds in League of Legends Arena is all about having best champion synergy between you and your duo partner. Apart from having the best meta picks for the mode, you will want to have a duo of champions who combo well with each other.
So if you are looking for the best Arena combinations in the MOBA then the list below will help you out.
The best champion duos in League of Legends Arena
Here is a list of all the champion duos whose kits synergize extremely well with each other and will help you to easily win out rounds in League of Legends Arena:
1) Bel’Veth and Lulu

Bel’Veth is an S+-tier champion in League of Legends Arena. She scales incredibly well into the late game, and once she gets her items and Augments going, she can melt through both tanks and carries. She has a lot of true damage built into her kit so all she needs to do is just stand her ground and attack.
This is why she needs to maximize her sustain with a support that compliments her kit. Lulu is the best option for this, as her Polymorph can CC the enemy while her Wild Groth can help Bel’Veth sustain her way through most meta-duo combinations.
2) Swain and Darius

Swain and Darius are S+ and S-tier picks respectively. The Noxians have amazing synergy between them and they both come with a lot of sustain, DoT effects, as well as burst. Plus their kit is versatile enough for you to build them the way you want.
You can either invest a lot of damage in them or build them as a tank with more sustain items or you can even make a hybrid build out of them. They have a lot of CC as well making them great picks for taking out hyper carries.
3) Cho’Gath and Yasuo

Yasuo and Cho’Gath make for one of the most perfect champion synergies in League of Legends Arena. Much of their match-round dominance comes from how well Cho’Gath is able to set enemies up for Yasuo’s Last Breath.
Cho’Gath also comes with true damage allowing him to instantly gobble up a champion once they reach the execution threshold. Additionally, Cho’Gath also has a silence making it quite difficult for picks that rely on abilities to go up against him.
4) Sett and Mordekaiser

Sett and Mordekaiser are both amazing duelists and can lack in champion synergy a bit when compared to the other picks on the list. However, this duo is very potent in Arena because Mordekaiser is capable of isolating a target by using Realm of Death.
If the duo you are up against has some amazing champion synergy, then you can make it very difficult for them to play against you by just whisking one of them away. For example, if you are up against a Bel’Veth and Lulu combo, Mordekaiser can just ult Bel’Veth allowing Sett to deal with Lulu.
5) Ryze and Zac

Ryze and Zac are an uncanny duo combination on this list. What makes them work is how Zac can absolutely disrupt everything that the enemy team tries to do while Ryze just keeps scaling into the late game till he is able to burst down any 2v2 match that he is up against.
They both are amazing in the later stages of the game. Zac becomes practically unkillable while Ryze keeps stacking more AP, and damage, along with a bit of HP and sustain with his itemization.
6) Ambessa and Leona

Ambessa has a lot of mobility and damage along with some of the best engage tools in the game. She goes extremely well with a CC-heavy champion like Leona where they can hard-commit on their enemy duo and instantly burst them down.
However, if the fight drags on, both the champions have enough sustain built into their kit that they will be able to keep going even if the enemy survives.
7) Master Yi and Janna

Master Yi and Janna are an amazing carry and support pair in League of Legends Arena. Janna helps peel for him quite well while providing him with additional sustain and can disrupt the enemy with her Tornados.
Master Yi, on the other hand, stacks attack speed and as his kit has a fair bit of true damage, he is capable of melting through tanks if he is left to free-hit them. Both of them have healing abilities allowing them to sustain their way through most encounters.
8) Vayne and Yuumi

The Vayne and Yuumi duo comes with very high mobility along with very high sustain. Vayne can shred through most completion when she gets going, so it’s very hard to take this duo down when Yuumi starts to enable her with her heals and CC.
The duo is also very easy to execute and you can pump a lot of AP into Yuumi to make her Prowling Projectile as burst-heavy as possible.
9) Kai’Sa and Galio

Galio comes with a lot of CC and engage tools in his kit. It pairs amazingly well with Kaisa’s passive allowing her to burst targets down very easily. Galio also comes with a lot of defense and sustain making it quite difficult to take him down once he has his items and Augments going.
Kai’Sa, on the other hand, has a fair bit of build versatility. As long as you are unlocking her evolutions you can then either get more attack speed, AP, or even AD.
10) Lucian and Naami

Lucian and Naami have always been the perfect pair on Summoner’s Rift and the fact remains the same in the Arena mode 2v2 maps as well. They have the best ADC and Support synergy in League of Legends and they very easily dominate any match-up as long as Lucian is dodging away from the enemy engage and Naami is landing her bubbles.